Intelligent equipment for drying toxic ingredients

Pharmaceutical industry attaches great importance to research and development in order to find new active components. As more and more components are identified to be toxic, it is very dangerous for operators to contact these drugs directly, which should be avoided as far as possible. Therefore, it is necessary to take measures to avoid drug contact with other substances.

Pharmaceutical industry attaches great importance to research and development in order to find new active components. As more and more components are identified to be toxic, it is very dangerous for operators to contact these drugs directly, which should be avoided as far as possible. Therefore, it is necessary to take measures to avoid drug contact with other substances.

Before the properties have been determined, vacuum drying oven is a wise choice for flash dryer drying new active components, because it has a series of advantages. This drying method can ensure the batch recovery of materials without product residue. In order to prevent the blocky active components from being broken down into small particles, Pink placed the patent of spray drying equipment on an isolator installed on the flange. Because the active substance is after the "reaction" or "centrifugal separation" steps before reaching the filtration stage, it is meaningful to integrate the filtration process step (pressure filtration) into the system and integrate it with the previous steps. This complex process unit must have the following functions:

■ operators must be protected from any toxic substances that may harm or contaminate the human body. Unlike the simple anti-virus measures such as anti-virus clothing, the anti-virus function of this system is evaluated and tested and certified.

■ sensitive highly concentrated products must also be isolated from the external environment to ensure quality. In the systems described above, products are usually kept in an environment where internal conditions are controlled.

■ no loss of product is very important in small batch production because these materials are usually expensive and highly toxic.

■ the design of the whole system must meet the requirements of GMP.

All surfaces of the system are smooth and observable and must be easy to clean to avoid cross contamination. The system consists of the following three process units:

■ mud filter unit

■ isolation device

■ vacuum drying oven

For the purpose of safety, the windows of the whole system are bolted to the isolation device, and the vibration fluidized bed can only be opened during the daily main monitoring. The unique feature of the system is that it can operate from both the front end and the back end. This makes the operation of mud filtration easier.

The oval handle flange of the drum scraper dryer located in the reinforcement area of the instrument allows workers to move the entire unit at will. Welded Boyer doors make it easy to remove excess material or tools. The system has three fast transfer ports, which can be used to control the feeding and discharging of products. The La calhene system allows the operator to open or seal sealed containers. The pipeline for feeding the system is arranged between the cover, the mud filter and the wall of the isolation device.

Mud filter integration

The mud filter is installed on the isolation device, which can bear the pressure of 3bar. The disc dryer product is placed in the filter chamber (the chamber is located inside the filter). The top cover is manually operated, and two air springs on it make it easier to open and close. It is especially important whether the device is easy to be combined with operation after implementation. The mud filter is pressurized with nitrogen to drive the liquid / volatile matter out of the filter.

The nature of the filter media also affects the degree of filtration. After filtration, open the mud filter and put the remaining filter in the loading tray. In order to ensure that even the smallest hollow pulp leaf dryer product residues will not be lost, the entire filter chamber can be removed from the filter, and the filter medium in the separator can be constantly replaced.

Drying stage

The plates containing the filter material are placed in the drying oven. The depth of the separator in the drying furnace is controlled at a small value to make the operation easier. Based on the consideration of ergonomics, in order to make it not too troublesome for the operator to take out the plate from the drying oven, a very precise and concise small door is designed to achieve this purpose. In fact, the door is divided into two parts. They are similar to the doors on an aircraft wing. They can be turned in a certain direction or rotated 180 degrees, so that the operator can see the inside surface of the device. The great advantage of this hot air oven drying oven is that all the shelves are welded on the side and back panel, and there is no gap or feeding channel in the whole device. All corners are smooth. The patented drying oven also has the characteristics of balanced temperature distribution (61 ℃ on the rack), so the results are repeatable no matter which shelf the operator uses to dry the products. After the drying of rotary kiln, the loading plate is removed from the drying furnace. The dried product is transferred to the sealed container through an RPT port. The sealed container can be detached from the system and introduced to the RPT port of another system. After use, the loading tray remains on the shelf. To reduce weight, the shelves inside the separator are made of plastic and can be easily placed and removed through the Boyer door.

Cleaning of the system

The two manual spray muzzle is mounted on the left and right sides of the system for cleaning. The muzzle is suspended on a hook at the bottom of the top floor of the isolator, so they have nothing to do with the normal operation of the system. Two drainage pipes are located at the bottom of the isolation device to facilitate the liquid discharge after cleaning. All directions from the inside of the furnace are visible to the operator. The welded frame is installed at the front with a small tilt angle to facilitate the flow of liquid after cleaning. The system has two push-pull filters, so there is a belt dryer without opening the device, which can replace the filter cartridge. The contaminated filter cartridge can be removed from the RTP port.

In order to ensure safety, the isolation device has overpressure limit value. The overpressure value of the outlet is related to the exhaust capacity of the exhaust device. The internal pressure is between - 50pA and - 120pa. If a handle is broken, the fan can increase the gas flow evenly and prevent the release of toxic substances. The instrument can be made of 316L stainless steel or nickel base alloy. The surface roughness is less than 0.4 μ m, which meets the requirements of pharmaceutical standards. Generally speaking, this system is an excellent choice for the production of toxic substances within a certain range.